Study shows toxin family binds to sugar receptors on human cells to cause damage

The structure of the CDC, suilysin, binding to a glycan receptor. This whole toxin is shown in the top left side. Domain 4 of the toxin (grey) is shown in complex with one of the glycans recognized by suilysin bottom right side.
Griffith Enterprise
Published
New Griffith University research has found that sugars decorating human cells allow toxins, produced by disease-causing bacteria, to bind to human cells and cause damage or death. The family of toxins known as cholesterol-dependent cytolysins (CDCs), are produced by bacteria such as Streptococcus pneumoniae, group A Streptococcus and Listeria monocytogenes, which cause pneumonia, invasive group […]

The importance of listing Strep A as a Neglected Tropical Disease

Griffith Enterprise
Published
Strep A, which can lead to serious illness and death if untreated, should be recognised as a Neglected Tropical Disease according to a leading infectious disease expert. Professor Michael Good AO, Principal Research Leader at Griffith University’s Institute for Glycomics, authored a paper published this week in PLOS Neglected Tropical Diseases. Neglected tropical diseases (NTDs) […]

Institute for Glycomics and Sienna Diagnostics to develop novel cancer diagnostic

Institute for Glycomics
Published
Researchers from the Institute for Glycomics and the University of Adelaide, have entered into an exclusive licensing deal with Sienna Cancer Diagnostics Ltd to commercialise a novel cancer diagnostic tool. Together, the teams of researchers have engineered a unique protein, called SubB2M, that binds specifically to a sugar molecule only present in cancer cells – a potential […]

Institute for Glycomics researchers tackle COVID-19

COVID-19
Published
Four teams of expert scientists from Griffith University’s Institute for Glycomics are targeting the virus SARS-CoV-2 to discover new vaccines and drugs to prevent or cure COVID-19. The teams are led by the Institute’s group leaders Professor Mark von Itzstein AO, Professor Michael Good AO, Professor Michael Jennings, and Professor Johnson Mak, all world-renowned research […]